Drug interactions
Fluvastatin + Tafamidis meglumine
Severity: Minor
Fluvastatin and Tafamidis meglumine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis meglumine inhibits BCRP in vitro and can raise exposure of BCRP substrates such as rosuvastatin. Fluvastatin is also a BCRP substrate, so its levels may rise modestly.
What this interaction means in plain words
Fluvastatin and Tafamidis meglumine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux by tafamidis.
What to do
No routine dose change is needed; monitor for muscle symptoms and reduce fluvastatin dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Tafamidis meglumine?
MediHelp rates the interaction as minor. Fluvastatin and Tafamidis meglumine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis meglumine inhibits BCRP in vitro and can raise exposure of BCRP substrates such as rosuvastatin. Fluvastatin is also a BCRP substrate, so its levels may rise modestly.
How serious is the interaction between Fluvastatin and Tafamidis meglumine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for muscle symptoms and reduce fluvastatin dose if they occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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