Drug interactions
Fluvastatin + Telmisartan-amlodipine
Severity: Minor
Fluvastatin and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been described as an OATP1B1 inhibitor in vitro, which could raise statin exposure. Fluvastatin is mainly metabolized by CYP2C9, and a clinically meaningful increase in myopathy risk is not well established.
What this interaction means in plain words
Fluvastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition by telmisartan could modestly raise fluvastatin levels.
What to do
No dose change is routinely needed. Ask patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Fluvastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan has been described as an OATP1B1 inhibitor in vitro, which could raise statin exposure. Fluvastatin is mainly metabolized by CYP2C9, and a clinically meaningful increase in myopathy risk is not well established.
How serious is the interaction between Fluvastatin and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Ask patients to report unexplained muscle pain or weakness.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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