Drug interactions
Fo-ti + Nateglinide
Severity: Minor
Fo-ti and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fo-ti (Polygonum multiflorum) has reported glucose-lowering effects in preclinical studies, so it could add to nateglinide's effect. Clinical evidence is lacking, and fo-ti has separate hepatotoxicity concerns.
What this interaction means in plain words
Fo-ti and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect; the mechanism is not established.
What to do
Discourage use of fo-ti because of liver toxicity risk; if it is used, monitor blood glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fo-ti and Nateglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Fo-ti with Nateglinide?
MediHelp rates the interaction as minor. Fo-ti and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fo-ti (Polygonum multiflorum) has reported glucose-lowering effects in preclinical studies, so it could add to nateglinide's effect. Clinical evidence is lacking, and fo-ti has separate hepatotoxicity concerns.
How serious is the interaction between Fo-ti and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage use of fo-ti because of liver toxicity risk; if it is used, monitor blood glucose.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
