Drug interactions
Folic acid + Pafolacianine
Severity: Moderate
Folic acid and Pafolacianine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pafolacianine is an optical imaging agent that targets folate receptors on ovarian cancer cells. Folic acid competes for these receptors and may reduce tumor uptake, causing lesions to be missed during surgery.
What this interaction means in plain words
Folic acid and Pafolacianine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive binding at folate receptors reduces pafolacianine uptake.
What to do
Withhold folic acid and folate-containing supplements for at least 48 hours before pafolacianine administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Phenobarbital Moderate
- Folic acid + Phenytoin Moderate
Frequently asked questions
Can I take Folic acid with Pafolacianine?
MediHelp rates the interaction as moderate. Folic acid and Pafolacianine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pafolacianine is an optical imaging agent that targets folate receptors on ovarian cancer cells. Folic acid competes for these receptors and may reduce tumor uptake, causing lesions to be missed during surgery.
How serious is the interaction between Folic acid and Pafolacianine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold folic acid and folate-containing supplements for at least 48 hours before pafolacianine administration.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Glucarpidase. The full list is on the Folic acid page.
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