Drug interactions
Folic acid + Glucarpidase
Severity: Moderate
Folic acid and Glucarpidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
What this interaction means in plain words
Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Glucarpidase belongs to Miscellaneous.
Why it happens
Glucarpidase is a carboxypeptidase that cleaves the terminal glutamate residue from folates, inactivating them.
What to do
Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
- Folic acid + Phenytoin Moderate
Other interactions of Glucarpidase
- Glucarpidase + Leucovorin Major
- Glucarpidase + Methotrexate Moderate
- Glucarpidase + Pemetrexed Minor
- Glucarpidase + Pralatrexate Minor
Frequently asked questions
Can I take Folic acid with Glucarpidase?
MediHelp rates the interaction as moderate. Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
How serious is the interaction between Folic acid and Glucarpidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Methotrexate. The full list is on the Folic acid page.
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