Drug interactions
Formoterol + Hydrochlorothiazide-telmisartan
Severity: Moderate
Formoterol and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and hydrochlorothiazide both lower serum potassium. Together they can cause clinically relevant hypokalemia, which may predispose to arrhythmias, particularly with high formoterol doses or in patients with hypoxia or heart disease.
What this interaction means in plain words
Formoterol and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Beta-2 agonism shifts potassium into cells while the thiazide increases renal potassium loss, giving additive hypokalemia.
What to do
Check potassium at baseline and during therapy in patients with severe asthma, COPD or cardiac disease. Replace potassium or add a potassium-sparing measure if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Formoterol and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol and hydrochlorothiazide both lower serum potassium. Together they can cause clinically relevant hypokalemia, which may predispose to arrhythmias, particularly with high formoterol doses or in patients with hypoxia or heart disease.
How serious is the interaction between Formoterol and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium at baseline and during therapy in patients with severe asthma, COPD or cardiac disease. Replace potassium or add a potassium-sparing measure if levels are low.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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