Drug interactions
Formoterol + Hydrochlorothiazide-valsartan
Severity: Moderate
Formoterol and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium through beta-2 stimulation, and hydrochlorothiazide also causes potassium loss. Together they may produce significant hypokalemia, especially at high formoterol doses or with hypoxia, increasing arrhythmia risk.
What this interaction means in plain words
Formoterol and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Beta-2 mediated cellular potassium uptake adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially in patients with severe asthma or COPD or those using higher doses of formoterol. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Formoterol and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium through beta-2 stimulation, and hydrochlorothiazide also causes potassium loss. Together they may produce significant hypokalemia, especially at high formoterol doses or with hypoxia, increasing arrhythmia risk.
How serious is the interaction between Formoterol and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in patients with severe asthma or COPD or those using higher doses of formoterol. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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