Drug interactions
Formoterol + Sacubitril-valsartan
Severity: Minor
Formoterol and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium via beta-2 stimulation, opposing the potassium-retaining effect of the angiotensin receptor blocker. Net potassium effect is generally small at inhaled doses, though cardiovascular effects may matter in susceptible patients.
What this interaction means in plain words
Formoterol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Formoterol belongs to Respiratory; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Beta-2-mediated intracellular potassium shift opposing angiotensin receptor blocker-related potassium retention.
What to do
No routine action is needed. Monitor serum potassium in patients on high doses or with other hypokalemic drugs or hyperkalemia risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Formoterol and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Formoterol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Formoterol can lower serum potassium via beta-2 stimulation, opposing the potassium-retaining effect of the angiotensin receptor blocker. Net potassium effect is generally small at inhaled doses, though cardiovascular effects may matter in susceptible patients.
How serious is the interaction between Formoterol and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor serum potassium in patients on high doses or with other hypokalemic drugs or hyperkalemia risk.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
