Drug interactions
Fosamprenavir + Garlic
Severity: Moderate
Fosamprenavir and Garlic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements may lower exposure to some HIV protease inhibitors, as shown for saquinavir. Reduced fosamprenavir (amprenavir) levels could lead to loss of viral suppression and resistance.
What this interaction means in plain words
Fosamprenavir and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable induction of CYP3A4 or P-glycoprotein by garlic constituents; the mechanism is not firmly established.
What to do
Advise patients to avoid garlic supplements while on fosamprenavir; dietary garlic is generally acceptable. Monitor HIV viral load if supplements are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Fosamprenavir with Garlic?
MediHelp rates the interaction as moderate. Fosamprenavir and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic supplements may lower exposure to some HIV protease inhibitors, as shown for saquinavir. Reduced fosamprenavir (amprenavir) levels could lead to loss of viral suppression and resistance.
How serious is the interaction between Fosamprenavir and Garlic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid garlic supplements while on fosamprenavir; dietary garlic is generally acceptable. Monitor HIV viral load if supplements are used.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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