Drug interactions
Fosamprenavir + Glyburide-metformin
Severity: Moderate
Fosamprenavir and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors such as amprenavir are associated with insulin resistance and hyperglycemia, which can worsen diabetes control. Higher doses of glyburide or metformin, or additional agents, may be needed.
What this interaction means in plain words
Fosamprenavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors cause insulin resistance and impaired glucose handling, opposing the effects of the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c when starting fosamprenavir and adjust antidiabetic therapy as needed. Reassess if the antiretroviral regimen is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Fosamprenavir with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fosamprenavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors such as amprenavir are associated with insulin resistance and hyperglycemia, which can worsen diabetes control. Higher doses of glyburide or metformin, or additional agents, may be needed.
How serious is the interaction between Fosamprenavir and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting fosamprenavir and adjust antidiabetic therapy as needed. Reassess if the antiretroviral regimen is changed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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