Drug interactions
Fosamprenavir + Ifosfamide
Severity: Moderate
Fosamprenavir and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and may reduce ifosfamide bioactivation and possibly its efficacy. It may also lower formation of neurotoxic metabolites, and the net effect is not well defined.
What this interaction means in plain words
Fosamprenavir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amprenavir reduces ifosfamide metabolism.
What to do
Monitor for treatment response and toxicity. Consider coordinating with HIV specialists on antiretroviral choice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Ifosfamide?
MediHelp rates the interaction as moderate. Fosamprenavir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and may reduce ifosfamide bioactivation and possibly its efficacy. It may also lower formation of neurotoxic metabolites, and the net effect is not well defined.
How serious is the interaction between Fosamprenavir and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment response and toxicity. Consider coordinating with HIV specialists on antiretroviral choice.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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