Drug interactions
Fosamprenavir + Insulin degludec-liraglutide
Severity: Moderate
Fosamprenavir and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors such as fosamprenavir can cause insulin resistance and hyperglycemia. This may reduce the effectiveness of insulin degludec/liraglutide and unmask or worsen diabetes.
What this interaction means in plain words
Fosamprenavir and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake, antagonizing antidiabetic therapy.
What to do
Monitor glucose closely when starting or stopping fosamprenavir. Increase the antidiabetic doses as needed and readjust after discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Fosamprenavir with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Fosamprenavir and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors such as fosamprenavir can cause insulin resistance and hyperglycemia. This may reduce the effectiveness of insulin degludec/liraglutide and unmask or worsen diabetes.
How serious is the interaction between Fosamprenavir and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting or stopping fosamprenavir. Increase the antidiabetic doses as needed and readjust after discontinuation.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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