Drug interactions
Fosamprenavir + Lidocaine
Severity: Moderate
Fosamprenavir and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) inhibits CYP3A4, which contributes to lidocaine metabolism. Systemic lidocaine levels may rise, increasing the risk of toxicity such as dizziness, seizures and cardiac effects, particularly with intravenous or repeated dosing.
What this interaction means in plain words
Fosamprenavir and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4-mediated lidocaine metabolism.
What to do
Monitor for signs of lidocaine toxicity and consider reducing the dose or infusion rate when systemic lidocaine is needed. Local anesthetic use at usual doses generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Fosamprenavir with Lidocaine?
MediHelp rates the interaction as moderate. Fosamprenavir and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (as amprenavir) inhibits CYP3A4, which contributes to lidocaine metabolism. Systemic lidocaine levels may rise, increasing the risk of toxicity such as dizziness, seizures and cardiac effects, particularly with intravenous or repeated dosing.
How serious is the interaction between Fosamprenavir and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of lidocaine toxicity and consider reducing the dose or infusion rate when systemic lidocaine is needed. Local anesthetic use at usual doses generally needs no change.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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