Drug interactions
Fosamprenavir + Nifedipine
Severity: Moderate
Fosamprenavir and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, inhibits CYP3A4, especially when boosted with ritonavir, and can raise nifedipine levels, causing hypotension and edema.
What this interaction means in plain words
Fosamprenavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4, reducing nifedipine metabolism.
What to do
Start nifedipine at a low dose and titrate to blood pressure response; monitor heart rate and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Fosamprenavir with Nifedipine?
MediHelp rates the interaction as moderate. Fosamprenavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active form of fosamprenavir, inhibits CYP3A4, especially when boosted with ritonavir, and can raise nifedipine levels, causing hypotension and edema.
How serious is the interaction between Fosamprenavir and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nifedipine at a low dose and titrate to blood pressure response; monitor heart rate and edema.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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