Drug interactions
Fosamprenavir + Quinine
Severity: Moderate
Fosamprenavir and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, inhibits CYP3A4, especially when boosted with ritonavir, and may increase quinine levels. This raises the risk of cinchonism and QT prolongation.
What this interaction means in plain words
Fosamprenavir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amprenavir reducing quinine metabolism.
What to do
Monitor ECG and for quinine toxicity; reduce quinine dose or duration if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Quinine?
MediHelp rates the interaction as moderate. Fosamprenavir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active form of fosamprenavir, inhibits CYP3A4, especially when boosted with ritonavir, and may increase quinine levels. This raises the risk of cinchonism and QT prolongation.
How serious is the interaction between Fosamprenavir and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for quinine toxicity; reduce quinine dose or duration if feasible.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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