Drug interactions
Fosamprenavir + Sunitinib
Severity: Major
Fosamprenavir and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, converted to amprenavir, is a CYP3A4 inhibitor, particularly when boosted with ritonavir. It can raise sunitinib concentrations and increase toxicity including hepatotoxicity and QT prolongation.
What this interaction means in plain words
Fosamprenavir and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 reduces sunitinib clearance.
What to do
Consider an alternative antiretroviral with less CYP3A4 inhibition. If unavoidable, reduce the sunitinib dose per labeling and monitor liver function, ECG and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Fosamprenavir with Sunitinib?
MediHelp rates the interaction as major. Fosamprenavir and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, converted to amprenavir, is a CYP3A4 inhibitor, particularly when boosted with ritonavir. It can raise sunitinib concentrations and increase toxicity including hepatotoxicity and QT prolongation.
How serious is the interaction between Fosamprenavir and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral with less CYP3A4 inhibition. If unavoidable, reduce the sunitinib dose per labeling and monitor liver function, ECG and tolerability.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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