Drug interactions
Fosamprenavir + Triamcinolone
Severity: Major
Fosamprenavir and Triamcinolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active metabolite amprenavir inhibits CYP3A4, especially when boosted with ritonavir, can increase triamcinolone exposure. This may cause Cushing syndrome and adrenal suppression.
What this interaction means in plain words
Fosamprenavir and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by amprenavir reduces triamcinolone metabolism.
What to do
Avoid prolonged or repeated triamcinolone; consider prednisolone or beclomethasone. If unavoidable, monitor for Cushingoid effects and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Fosamprenavir with Triamcinolone?
MediHelp rates the interaction as major. Fosamprenavir and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, whose active metabolite amprenavir inhibits CYP3A4, especially when boosted with ritonavir, can increase triamcinolone exposure. This may cause Cushing syndrome and adrenal suppression.
How serious is the interaction between Fosamprenavir and Triamcinolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged or repeated triamcinolone; consider prednisolone or beclomethasone. If unavoidable, monitor for Cushingoid effects and adrenal suppression.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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