Drug interactions
Fosamprenavir + Vinorelbine
Severity: Moderate
Fosamprenavir and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, converted to amprenavir, inhibits CYP3A4, particularly when boosted with ritonavir, and may raise vinorelbine concentrations. Increased myelosuppression and neurotoxicity are possible.
What this interaction means in plain words
Fosamprenavir and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated vinorelbine metabolism.
What to do
Monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose if toxicity occurs. Consider an alternative antiretroviral where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Fosamprenavir with Vinorelbine?
MediHelp rates the interaction as moderate. Fosamprenavir and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, converted to amprenavir, inhibits CYP3A4, particularly when boosted with ritonavir, and may raise vinorelbine concentrations. Increased myelosuppression and neurotoxicity are possible.
How serious is the interaction between Fosamprenavir and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose if toxicity occurs. Consider an alternative antiretroviral where feasible.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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