Drug interactions
Foscarnet + Ioversol
Severity: Moderate
Foscarnet and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause contrast-associated acute kidney injury, and foscarnet is itself significantly nephrotoxic. Giving them close together may increase the risk and severity of renal impairment, especially in dehydrated patients or those with existing kidney disease.
What this interaction means in plain words
Foscarnet and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through direct tubular injury and renal hemodynamic effects.
What to do
Ensure adequate hydration and use the lowest necessary contrast dose. Monitor serum creatinine and electrolytes before and for several days after contrast, and adjust foscarnet dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Ioversol?
MediHelp rates the interaction as moderate. Foscarnet and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause contrast-associated acute kidney injury, and foscarnet is itself significantly nephrotoxic. Giving them close together may increase the risk and severity of renal impairment, especially in dehydrated patients or those with existing kidney disease.
How serious is the interaction between Foscarnet and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and use the lowest necessary contrast dose. Monitor serum creatinine and electrolytes before and for several days after contrast, and adjust foscarnet dose to renal function.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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