Drug interactions
Foscarnet + Methoxyflurane
Severity: Major
Foscarnet and Methoxyflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride ions that are toxic to the kidney, and foscarnet is also nephrotoxic. Combined exposure increases the risk of acute kidney injury.
What this interaction means in plain words
Foscarnet and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from fluoride-mediated tubular injury and foscarnet tubular toxicity.
What to do
Avoid methoxyflurane in patients receiving foscarnet or with renal impairment. If it is used, monitor renal function and keep the patient well hydrated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Methoxyflurane?
MediHelp rates the interaction as major. Foscarnet and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane releases fluoride ions that are toxic to the kidney, and foscarnet is also nephrotoxic. Combined exposure increases the risk of acute kidney injury.
How serious is the interaction between Foscarnet and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methoxyflurane in patients receiving foscarnet or with renal impairment. If it is used, monitor renal function and keep the patient well hydrated.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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