Drug interactions
Foscarnet + Neomycin po
Severity: Moderate
Foscarnet and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic nephrotoxicity is usually limited. However, absorption can rise with inflamed bowel or renal impairment, and foscarnet is strongly nephrotoxic. Systemic neomycin could then add to kidney and hearing damage.
What this interaction means in plain words
Foscarnet and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive nephrotoxicity and ototoxicity if neomycin is absorbed systemically.
What to do
Monitor serum creatinine and electrolytes during concurrent use, especially with renal impairment or bowel disease. Avoid prolonged neomycin courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Neomycin po?
MediHelp rates the interaction as moderate. Foscarnet and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed, so systemic nephrotoxicity is usually limited. However, absorption can rise with inflamed bowel or renal impairment, and foscarnet is strongly nephrotoxic. Systemic neomycin could then add to kidney and hearing damage.
How serious is the interaction between Foscarnet and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes during concurrent use, especially with renal impairment or bowel disease. Avoid prolonged neomycin courses.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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