Drug interactions
Foscarnet + Peramivir
Severity: Moderate
Foscarnet and Peramivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is eliminated mainly by the kidney, and foscarnet can impair renal function. Reduced kidney function may raise peramivir exposure, so the combination calls for attention to renal status.
What this interaction means in plain words
Foscarnet and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Foscarnet-induced nephrotoxicity may reduce renal clearance of peramivir.
What to do
Monitor renal function during co-therapy and adjust the peramivir dose according to creatinine clearance. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Peramivir?
MediHelp rates the interaction as moderate. Foscarnet and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peramivir is eliminated mainly by the kidney, and foscarnet can impair renal function. Reduced kidney function may raise peramivir exposure, so the combination calls for attention to renal status.
How serious is the interaction between Foscarnet and Peramivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during co-therapy and adjust the peramivir dose according to creatinine clearance. Ensure adequate hydration.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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