Drug interactions
Foscarnet + Promazine
Severity: Moderate
Foscarnet and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine antipsychotic with QT-prolonging potential. Foscarnet may add to this and disturb electrolytes, increasing the risk of ventricular arrhythmia.
What this interaction means in plain words
Foscarnet and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with foscarnet-related electrolyte depletion.
What to do
Check ECG at baseline and during treatment, and correct potassium, magnesium and calcium. Consider an alternative agent if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Promazine?
MediHelp rates the interaction as moderate. Foscarnet and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine antipsychotic with QT-prolonging potential. Foscarnet may add to this and disturb electrolytes, increasing the risk of ventricular arrhythmia.
How serious is the interaction between Foscarnet and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during treatment, and correct potassium, magnesium and calcium. Consider an alternative agent if QTc becomes prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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