Drug interactions
Foscarnet + Protriptyline
Severity: Moderate
Foscarnet and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that can prolong QT and conduction intervals. Foscarnet may add to this and cause electrolyte disturbances, modestly raising arrhythmia risk.
What this interaction means in plain words
Foscarnet and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with foscarnet-related electrolyte loss.
What to do
Obtain an ECG in patients with cardiac risk factors and monitor QTc. Correct potassium, magnesium and calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Protriptyline?
MediHelp rates the interaction as moderate. Foscarnet and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that can prolong QT and conduction intervals. Foscarnet may add to this and cause electrolyte disturbances, modestly raising arrhythmia risk.
How serious is the interaction between Foscarnet and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac risk factors and monitor QTc. Correct potassium, magnesium and calcium.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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