Drug interactions
Foscarnet + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Foscarnet and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet chelates divalent cations and commonly causes hypocalcemia, hypomagnesemia and other electrolyte shifts that can trigger seizures and arrhythmias. Bowel-preparation products can cause fluid loss and further electrolyte changes, adding to this risk and to the risk of renal injury.
What this interaction means in plain words
Foscarnet and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte disturbances, with volume depletion increasing foscarnet nephrotoxicity.
What to do
Maintain hydration and check electrolytes, including calcium, magnesium, potassium and phosphate, and renal function before and after bowel preparation. Correct abnormalities before continuing foscarnet.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Foscarnet and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet chelates divalent cations and commonly causes hypocalcemia, hypomagnesemia and other electrolyte shifts that can trigger seizures and arrhythmias. Bowel-preparation products can cause fluid loss and further electrolyte changes, adding to this risk and to the risk of renal injury.
How serious is the interaction between Foscarnet and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and check electrolytes, including calcium, magnesium, potassium and phosphate, and renal function before and after bowel preparation. Correct abnormalities before continuing foscarnet.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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