Drug interactions
Foscarnet + Streptozocin
Severity: Major
Foscarnet and Streptozocin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin has dose-related renal toxicity, often showing as proteinuria and tubular damage, and foscarnet is also nephrotoxic. Used together they may considerably increase the risk of kidney injury.
What this interaction means in plain words
Foscarnet and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through direct renal tubular injury.
What to do
Avoid concurrent use when possible. If needed, monitor creatinine, electrolytes and urinary protein frequently, maintain hydration and adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Streptozocin?
MediHelp rates the interaction as major. Foscarnet and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptozocin has dose-related renal toxicity, often showing as proteinuria and tubular damage, and foscarnet is also nephrotoxic. Used together they may considerably increase the risk of kidney injury.
How serious is the interaction between Foscarnet and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If needed, monitor creatinine, electrolytes and urinary protein frequently, maintain hydration and adjust doses to renal function.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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