Drug interactions
Foscarnet + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Foscarnet and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can prolong the QT interval and cause hypokalemia and tachycardia. Foscarnet also prolongs QT and may lower electrolytes, so combined use could heighten arrhythmia risk, although inhaled systemic exposure is low.
What this interaction means in plain words
Foscarnet and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and foscarnet electrolyte disturbances adding risk.
What to do
Monitor ECG and serum potassium, magnesium and calcium in patients on both drugs, especially those with cardiac disease. Correct electrolyte abnormalities promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Foscarnet and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can prolong the QT interval and cause hypokalemia and tachycardia. Foscarnet also prolongs QT and may lower electrolytes, so combined use could heighten arrhythmia risk, although inhaled systemic exposure is low.
How serious is the interaction between Foscarnet and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, magnesium and calcium in patients on both drugs, especially those with cardiac disease. Correct electrolyte abnormalities promptly.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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