Drug interactions
Fosinopril + Metformin
Severity: Moderate
Fosinopril and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may slightly enhance glucose lowering, so hypoglycemia is possible though uncommon with metformin alone. If fosinopril causes acute kidney injury, metformin can accumulate and raise the risk of lactic acidosis.
What this interaction means in plain words
Fosinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, and any ACE inhibitor-related fall in renal function can reduce metformin clearance.
What to do
Monitor blood glucose and renal function after starting fosinopril. Hold metformin during acute illness with dehydration or if renal function declines significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril and Metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Metformin
Frequently asked questions
Can I take Fosinopril with Metformin?
MediHelp rates the interaction as moderate. Fosinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may slightly enhance glucose lowering, so hypoglycemia is possible though uncommon with metformin alone. If fosinopril causes acute kidney injury, metformin can accumulate and raise the risk of lactic acidosis.
How serious is the interaction between Fosinopril and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function after starting fosinopril. Hold metformin during acute illness with dehydration or if renal function declines significantly.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
