Drug interactions
Fosinopril + Methylphenidate transdermal
Severity: Moderate
Fosinopril and Methylphenidate transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can raise blood pressure and heart rate, and may therefore partly oppose the antihypertensive effect of fosinopril. The effect is usually modest.
What this interaction means in plain words
Fosinopril and Methylphenidate transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic pressor effect of methylphenidate opposes ACE inhibitor blood pressure lowering.
What to do
Monitor blood pressure and heart rate regularly after starting or adjusting methylphenidate, and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Methylphenidate transdermal?
MediHelp rates the interaction as moderate. Fosinopril and Methylphenidate transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can raise blood pressure and heart rate, and may therefore partly oppose the antihypertensive effect of fosinopril. The effect is usually modest.
How serious is the interaction between Fosinopril and Methylphenidate transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly after starting or adjusting methylphenidate, and adjust antihypertensive therapy if control is lost.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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