Drug interactions
Fosinopril + Moxisylyte
Severity: Moderate
Fosinopril and Moxisylyte: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-adrenergic blocker with vasodilating properties, and combining it with an ACE inhibitor can produce additive blood pressure lowering. Patients may have an exaggerated hypotensive response, particularly after the first doses or a dose increase.
What this interaction means in plain words
Fosinopril and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation through alpha-adrenoceptor blockade and inhibition of angiotensin II formation.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or the dose is changed. Consider starting with low doses and advising the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Moxisylyte?
MediHelp rates the interaction as moderate. Fosinopril and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-adrenergic blocker with vasodilating properties, and combining it with an ACE inhibitor can produce additive blood pressure lowering. Patients may have an exaggerated hypotensive response, particularly after the first doses or a dose increase.
How serious is the interaction between Fosinopril and Moxisylyte?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or the dose is changed. Consider starting with low doses and advising the patient to rise slowly.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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