Drug interactions
Fosinopril + Nesiritide
Severity: Moderate
Fosinopril and Nesiritide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent intravenous vasodilator, and ACE inhibitors also lower blood pressure. Together they can cause additive hypotension, which is more likely in volume-depleted patients or those with renal impairment.
What this interaction means in plain words
Fosinopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation via natriuretic peptide receptor activation and reduced angiotensin II production.
What to do
Monitor blood pressure closely during nesiritide infusion and reduce or stop the infusion if symptomatic hypotension occurs. Check renal function in patients on both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril and Nesiritide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Nesiritide?
MediHelp rates the interaction as moderate. Fosinopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent intravenous vasodilator, and ACE inhibitors also lower blood pressure. Together they can cause additive hypotension, which is more likely in volume-depleted patients or those with renal impairment.
How serious is the interaction between Fosinopril and Nesiritide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during nesiritide infusion and reduce or stop the infusion if symptomatic hypotension occurs. Check renal function in patients on both drugs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
