Drug interactions
Fosinopril + Parecoxib
Severity: Moderate
Fosinopril and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a COX-2 selective NSAID, can reduce the blood pressure lowering effect of fosinopril. The combination may also impair renal function, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Fosinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing ACE inhibition.
What to do
Maintain hydration and monitor blood pressure, creatinine and potassium, especially at initiation. Limit parecoxib to the shortest duration needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Parecoxib?
MediHelp rates the interaction as moderate. Fosinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a COX-2 selective NSAID, can reduce the blood pressure lowering effect of fosinopril. The combination may also impair renal function, particularly in elderly or volume-depleted patients.
How serious is the interaction between Fosinopril and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, creatinine and potassium, especially at initiation. Limit parecoxib to the shortest duration needed.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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