Drug interactions
Fosinopril + Potassium citrate-citric acid
Severity: Moderate
Fosinopril and Potassium citrate-citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosinopril reduces aldosterone secretion and potassium excretion, and potassium citrate supplies extra potassium. Together they may produce hyperkalemia, especially in patients with renal impairment.
What this interaction means in plain words
Fosinopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Potassium citrate-citric acid belongs to Gastrointestinal Tract.
Why it happens
ACE inhibition lowers aldosterone, decreasing renal potassium elimination on top of the supplemental potassium.
What to do
Monitor serum potassium and renal function at baseline and periodically. Adjust the potassium dose or stop it if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril and Potassium citrate-citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Potassium citrate-citric acid
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Potassium citrate-citric acid?
MediHelp rates the interaction as moderate. Fosinopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosinopril reduces aldosterone secretion and potassium excretion, and potassium citrate supplies extra potassium. Together they may produce hyperkalemia, especially in patients with renal impairment.
How serious is the interaction between Fosinopril and Potassium citrate-citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at baseline and periodically. Adjust the potassium dose or stop it if potassium rises.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
