Drug interactions
Fosinopril + Salicylates
Severity: Moderate
Fosinopril and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylsalicylate salicylates at anti-inflammatory doses may blunt the antihypertensive effect of fosinopril. In volume-depleted, elderly or renally impaired patients they may also worsen renal function.
What this interaction means in plain words
Fosinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces vasodilation and renal sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, creatinine and potassium with regular anti-inflammatory salicylate use. Prefer paracetamol where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Salicylates?
MediHelp rates the interaction as moderate. Fosinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylsalicylate salicylates at anti-inflammatory doses may blunt the antihypertensive effect of fosinopril. In volume-depleted, elderly or renally impaired patients they may also worsen renal function.
How serious is the interaction between Fosinopril and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with regular anti-inflammatory salicylate use. Prefer paracetamol where appropriate.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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