Drug interactions
Fosinopril + Sodium citrate / citric acid
Severity: Minor
Fosinopril and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium citrate acts as an antacid and could slightly reduce fosinopril absorption. It also adds a sodium load that may marginally weaken blood pressure control. Clinical impact is usually minor.
What this interaction means in plain words
Fosinopril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduced absorption of fosinopril from raised gastric pH, plus sodium load, though the mechanism is not firmly established.
What to do
Separate doses by about two hours where practical. Monitor blood pressure if the citrate is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Fosinopril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium citrate acts as an antacid and could slightly reduce fosinopril absorption. It also adds a sodium load that may marginally weaken blood pressure control. Clinical impact is usually minor.
How serious is the interaction between Fosinopril and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by about two hours where practical. Monitor blood pressure if the citrate is used regularly.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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