Drug interactions
Fosinopril + Telmisartan
Severity: Major
Fosinopril and Telmisartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. Trials in broad populations showed more hyperkalemia, hypotension and renal function decline without a clear outcome benefit.
What this interaction means in plain words
Fosinopril and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosinopril belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two points, reducing aldosterone and glomerular efferent tone.
What to do
Avoid routine combination and use a single RAS blocker. If the combination is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Fosinopril with Telmisartan?
MediHelp rates the interaction as major. Fosinopril and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. Trials in broad populations showed more hyperkalemia, hypotension and renal function decline without a clear outcome benefit.
How serious is the interaction between Fosinopril and Telmisartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination and use a single RAS blocker. If the combination is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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