Drug interactions
Fosinopril + Trifluoperazine
Severity: Moderate
Fosinopril and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics such as trifluoperazine can cause orthostatic hypotension through alpha-adrenergic blockade. With fosinopril this may increase the hypotensive effect, particularly at initiation.
What this interaction means in plain words
Fosinopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade combined with ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing doses. Advise slow postural changes and adjust doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Trifluoperazine?
MediHelp rates the interaction as moderate. Fosinopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics such as trifluoperazine can cause orthostatic hypotension through alpha-adrenergic blockade. With fosinopril this may increase the hypotensive effect, particularly at initiation.
How serious is the interaction between Fosinopril and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing doses. Advise slow postural changes and adjust doses if hypotension occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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