Drug interactions
Fosinopril + Zotepine
Severity: Moderate
Fosinopril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine blocks alpha-1 adrenoceptors and can cause orthostatic hypotension. With an ACE inhibitor, blood pressure lowering may be additive, especially at initiation or after dose increases.
What this interaction means in plain words
Fosinopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism by zotepine and renin-angiotensin inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Increase doses gradually and counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Zotepine?
MediHelp rates the interaction as moderate. Fosinopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine blocks alpha-1 adrenoceptors and can cause orthostatic hypotension. With an ACE inhibitor, blood pressure lowering may be additive, especially at initiation or after dose increases.
How serious is the interaction between Fosinopril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Increase doses gradually and counsel the patient to rise slowly.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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