Drug interactions
Fosphenytoin + Pantoprazole
Severity: Minor
Fosphenytoin and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, the active form of fosphenytoin, can induce CYP2C19 and CYP3A4 and may lower pantoprazole concentrations. Reduced acid suppression is possible, and PPIs may also modestly alter phenytoin levels.
What this interaction means in plain words
Fosphenytoin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosphenytoin belongs to Central Nervous System; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Enzyme induction by phenytoin increases the metabolism of pantoprazole.
What to do
Monitor for inadequate acid suppression and adjust the pantoprazole dose if needed. Check phenytoin levels if the clinical response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fosphenytoin with Pantoprazole?
MediHelp rates the interaction as minor. Fosphenytoin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin, the active form of fosphenytoin, can induce CYP2C19 and CYP3A4 and may lower pantoprazole concentrations. Reduced acid suppression is possible, and PPIs may also modestly alter phenytoin levels.
How serious is the interaction between Fosphenytoin and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for inadequate acid suppression and adjust the pantoprazole dose if needed. Check phenytoin levels if the clinical response changes.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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