Drug interactions
Frovatriptan + Isoniazid
Severity: Minor
Frovatriptan and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO inhibitory properties, so additive serotonergic effects with a triptan are theoretically possible. Frovatriptan is mainly cleared by CYP1A2 and is not significantly MAO-A dependent, so a clinically relevant interaction is unlikely.
What this interaction means in plain words
Frovatriptan and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic activity through weak MAO inhibition by isoniazid.
What to do
No routine adjustment is needed. Counsel the patient to report agitation, tremor, sweating or fever.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Frovatriptan and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Isoniazid?
MediHelp rates the interaction as minor. Frovatriptan and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak MAO inhibitory properties, so additive serotonergic effects with a triptan are theoretically possible. Frovatriptan is mainly cleared by CYP1A2 and is not significantly MAO-A dependent, so a clinically relevant interaction is unlikely.
How serious is the interaction between Frovatriptan and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Counsel the patient to report agitation, tremor, sweating or fever.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
