Drug interactions
Frovatriptan + Lofepramine
Severity: Moderate
Frovatriptan and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with serotonin reuptake inhibiting activity, so use with a triptan may theoretically cause serotonin syndrome. Clinical reports are scarce.
What this interaction means in plain words
Frovatriptan and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity from tricyclic reuptake inhibition and triptan receptor agonism.
What to do
Advise the patient about serotonin syndrome symptoms and monitor after starting or changing doses. Stop the combination if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Lofepramine?
MediHelp rates the interaction as moderate. Frovatriptan and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with serotonin reuptake inhibiting activity, so use with a triptan may theoretically cause serotonin syndrome. Clinical reports are scarce.
How serious is the interaction between Frovatriptan and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about serotonin syndrome symptoms and monitor after starting or changing doses. Stop the combination if symptoms emerge.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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