Drug interactions
Frovatriptan + Loxapine inhaled
Severity: Moderate
Frovatriptan and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is an antipsychotic with dopamine D2 and serotonin 5-HT2A antagonism. Combined with a triptan there is a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome, although systemic exposure to a single inhaled dose is limited.
What this interaction means in plain words
Frovatriptan and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping serotonergic effects with dopamine blockade; theoretical.
What to do
Monitor for hyperthermia, rigidity, mental status changes and autonomic instability after dosing. Discontinue both and treat if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Loxapine inhaled?
MediHelp rates the interaction as moderate. Frovatriptan and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine is an antipsychotic with dopamine D2 and serotonin 5-HT2A antagonism. Combined with a triptan there is a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome, although systemic exposure to a single inhaled dose is limited.
How serious is the interaction between Frovatriptan and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, mental status changes and autonomic instability after dosing. Discontinue both and treat if suspected.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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