Drug interactions
Frovatriptan + Methylene blue
Severity: Major
Frovatriptan and Methylene blue: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylene blue inhibits MAO-A and can cause serotonin syndrome when given with serotonergic drugs such as triptans. Severe CNS toxicity has been reported with this class of combination.
What this interaction means in plain words
Frovatriptan and Methylene blue can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO-A inhibition by methylene blue increases synaptic serotonin, adding to the serotonergic effect of frovatriptan.
What to do
Avoid if possible; if methylene blue is urgently needed, stop frovatriptan and monitor for serotonin toxicity. Resume frovatriptan 24 hours after the last methylene blue dose or after two weeks, whichever comes first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Methylene blue?
MediHelp rates the interaction as major. Frovatriptan and Methylene blue can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylene blue inhibits MAO-A and can cause serotonin syndrome when given with serotonergic drugs such as triptans. Severe CNS toxicity has been reported with this class of combination.
How serious is the interaction between Frovatriptan and Methylene blue?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if methylene blue is urgently needed, stop frovatriptan and monitor for serotonin toxicity. Resume frovatriptan 24 hours after the last methylene blue dose or after two weeks, whichever comes first.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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