Drug interactions
Frovatriptan + Molindone
Severity: Moderate
Frovatriptan and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Molindone is a dopamine-blocking antipsychotic. Combined with a triptan, a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome exists, though documented cases are rare.
What this interaction means in plain words
Frovatriptan and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonergic modulation with dopamine D2 blockade; theoretical.
What to do
Monitor for fever, rigidity, mental status change and autonomic instability. Stop the agents and treat if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Molindone?
MediHelp rates the interaction as moderate. Frovatriptan and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Molindone is a dopamine-blocking antipsychotic. Combined with a triptan, a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome exists, though documented cases are rare.
How serious is the interaction between Frovatriptan and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fever, rigidity, mental status change and autonomic instability. Stop the agents and treat if toxicity is suspected.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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