Drug interactions
Frovatriptan + Nefazodone
Severity: Moderate
Frovatriptan and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity through reuptake inhibition and 5-HT2A antagonism, so adding a triptan may theoretically cause serotonin syndrome. Documented cases are limited.
What this interaction means in plain words
Frovatriptan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects of nefazodone reuptake inhibition and frovatriptan 5-HT1B/1D agonism.
What to do
Monitor for signs of serotonin toxicity, particularly after dose changes. Discontinue the agents and give supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Nefazodone?
MediHelp rates the interaction as moderate. Frovatriptan and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity through reuptake inhibition and 5-HT2A antagonism, so adding a triptan may theoretically cause serotonin syndrome. Documented cases are limited.
How serious is the interaction between Frovatriptan and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity, particularly after dose changes. Discontinue the agents and give supportive care if it occurs.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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