Drug interactions
Frovatriptan + Olanzapine
Severity: Moderate
Frovatriptan and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans act on serotonin receptors and antipsychotics may be implicated in serotonin toxicity or neuroleptic malignant syndrome when combined with serotonergic drugs. The risk is considered low and rests mostly on theoretical grounds and sparse reports.
What this interaction means in plain words
Frovatriptan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is not firmly established.
What to do
Counsel the patient to report agitation, tremor, fever, sweating or muscle rigidity. Discontinue the triptan and seek urgent evaluation if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Olanzapine?
MediHelp rates the interaction as moderate. Frovatriptan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans act on serotonin receptors and antipsychotics may be implicated in serotonin toxicity or neuroleptic malignant syndrome when combined with serotonergic drugs. The risk is considered low and rests mostly on theoretical grounds and sparse reports.
How serious is the interaction between Frovatriptan and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, fever, sweating or muscle rigidity. Discontinue the triptan and seek urgent evaluation if these occur.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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