Drug interactions
Frovatriptan + Peginterferon alfa 2a
Severity: Minor
Frovatriptan and Peginterferon alfa 2a: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Frovatriptan is partly metabolized by CYP1A2, which peginterferon alfa-2a can inhibit modestly, so frovatriptan levels may rise slightly. Clinical consequences are expected to be small.
What this interaction means in plain words
Frovatriptan and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Peginterferon alfa 2a belongs to Anti Virals.
Why it happens
Interferon-mediated inhibition of CYP1A2 reduces frovatriptan metabolism.
What to do
No dose change is generally needed; monitor for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2a
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Peginterferon alfa 2a?
MediHelp rates the interaction as minor. Frovatriptan and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Frovatriptan is partly metabolized by CYP1A2, which peginterferon alfa-2a can inhibit modestly, so frovatriptan levels may rise slightly. Clinical consequences are expected to be small.
How serious is the interaction between Frovatriptan and Peginterferon alfa 2a?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxycarbamide. The full list is on the Peginterferon alfa 2a page.
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