Drug interactions
Frovatriptan + Pimozide
Severity: Minor
Frovatriptan and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Frovatriptan is cleared mainly by CYP1A2 and other pathways, and pimozide does not significantly alter its exposure. A serotonin syndrome or neuroleptic malignant syndrome risk is only theoretical.
What this interaction means in plain words
Frovatriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Theoretical serotonergic and dopaminergic pharmacodynamic overlap; no established mechanism.
What to do
No routine adjustment is needed. Advise the patient to report fever, agitation, muscle rigidity or tremor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Pimozide?
MediHelp rates the interaction as minor. Frovatriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Frovatriptan is cleared mainly by CYP1A2 and other pathways, and pimozide does not significantly alter its exposure. A serotonin syndrome or neuroleptic malignant syndrome risk is only theoretical.
How serious is the interaction between Frovatriptan and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Advise the patient to report fever, agitation, muscle rigidity or tremor.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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