Drug interactions
Frovatriptan + Rifampin
Severity: Minor
Frovatriptan and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces many hepatic enzymes, including CYP1A2, and may lower frovatriptan levels. Any loss of migraine efficacy is likely modest.
What this interaction means in plain words
Frovatriptan and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induction of CYP1A2 increases frovatriptan metabolism.
What to do
No dose change is routinely needed. Review efficacy and consider an alternative triptan if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Rifampin?
MediHelp rates the interaction as minor. Frovatriptan and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin induces many hepatic enzymes, including CYP1A2, and may lower frovatriptan levels. Any loss of migraine efficacy is likely modest.
How serious is the interaction between Frovatriptan and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Review efficacy and consider an alternative triptan if response is lost.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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