Drug interactions
Frovatriptan + Same
Severity: Moderate
Frovatriptan and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) supplements have been associated with serotonergic effects and may add to those of frovatriptan. Serotonin syndrome is possible but uncommon.
What this interaction means in plain words
Frovatriptan and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity; SAMe's serotonergic mechanism is not fully established.
What to do
Ask about SAMe use and monitor for tremor, agitation, sweating and diarrhea. Stop SAMe if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Same?
MediHelp rates the interaction as moderate. Frovatriptan and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) supplements have been associated with serotonergic effects and may add to those of frovatriptan. Serotonin syndrome is possible but uncommon.
How serious is the interaction between Frovatriptan and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about SAMe use and monitor for tremor, agitation, sweating and diarrhea. Stop SAMe if symptoms appear.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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